Associate Professor Greg Cooney
Principal Research Fellow; Group Leader and Deputy Director, Diabetes & Obesity Research Program, Garvan Institute of Medical Research; NHMRC Senior Research Fellow; Conjoint Associate Professor, Faculty of Medicine, The University of New South Wales
Email: g.cooney 'at' garvan.org.au
Research Group: Cooney
Education
1980 PhD (Biochemistry) University of Sydney
1976 BSc (Hons 1) University of Sydney
Awards
Roslyn Flora Goulston Prize for Biochemistry.
Eleanor Sophia Wood Travelling Fellowship
NHMRC Senior Research Fellowship
Publications
Molero JC, Turner N, Thien CB, Langdon WY, James DE, Cooney GJ. Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action. Diabetes 2006; 55(12):3411-7.
Parkes HA, Preston E, Wilks D, Ballesteros M, Carpenter L, Wood L, Kraegen EW, Furler SM, Cooney GJ. Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo. Am J Physiol Endocrinol Metab 2006; 291(4):E737-44.
Cleasby ME, Davey JR, Reinten TA, Graham MW, James DE, Kraegen EW, Cooney GJ. Acute bidirectional manipulation of muscle glucose uptake by in vivo electro-transfer of constructs targeting glucose transporter genes. Diabetes 2005; 54(9):2702-11.
Frangioudakis G, Ye JM, Cooney GJ. Both saturated and n-6 polyunsaturated fat diets reduce phosphorylation of IRS-1 and PKB in muscle during the initial stages of in vivo insulin stimulation. Endocrinology 2005; 146(12):5596-603.
Molero JC, Jensen TE, Withers PC, Couzens M, Herzog H, Thien CBF, Langdon WY, Walder K, Murphy MA, Bowtell DDL, James DE, Cooney GJ. c-Cbl deficient mice have reduced adiposity, higher energy expenditure and improved peripheral insulin action. Journal of Clinical Investigation 2004; 114(9):1326-1333.
Cooney GJ, Lyons RJ, Crew AJ, Jensen TE, Molero JC, James DE, Mitchell CJ, Biden TJ, Ormandy CJ, Daly RJ. Improved glucose homeostasis and enhanced insulin signaling in Grb14-deficient mice. EMBO J 2004; 23(3):582-593.
Hegarty BD, Furler SM, Oakes ND, Kraegen EW, Cooney GJ. PPAR activation induces tissue specific effects on fatty acid uptake and metabolism in vivo - a study using the novel PPAR α/γ agonist Tesaglitazar. Endocrinology 2004; 145(7):3158-3164.
Thompson AL, Cooney GJ. Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance. Diabetes 2000; 49:1761-1765.
Ellis BA, Poynten A, Lowy A, Furler SM, Chisholm DJ, Kraegen EW, Cooney GJ. Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. Am J Physiol (Endocrinol Metab) 2000; 279:E554-E560.
Parker RMC, Wisialowski T, Kraegen E, Herzog H, Cooney G. Adrenalectomy reduces NPY-induced insulin release and decreases Y1 and Y5 receptor gene expression in the ventromedial hypothalamus of rats. J Clin Invest 2000; 105:1253-1259.
Wisialowski T, Parker R, Preston E, Sainsbury A, Kraegen E, Herzog H, Cooney G. Adrenalectomy reduces neuropeptide Y-induced insulin release and NPY receptor expression in the rat ventromedial hypothalamus. J Clin Invest 2000; 105:1253-1259.
