Dr Ross Laybutt
Senior Research Officer; Group Leader, Diabetes and Obesity Research Program, Garvan Institute of Medical Research; Conjoint Senior Lecturer, The University of New South Wales
Email: r.laybutt 'at' garvan.org.au
Research Group: Laybutt
Education
1994 BSc (Hons) Class 1, The University of New South Wales
1998 PhD, The University of New South Wales
Awards and Honours (NEED DATES)
Juvenile Diabetes Foundation Post-Doctoral Fellowship
RD Wright Biomedical Career Development Award (NHMRC)
NHMRC Early Career Researcher Award, Australian Academy of Science
Publications
Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GC. Influence of diabetes on the loss of beta cell differentiation after islet transplantation. Diabetologia 2007; 50:2117-2125
Schmitz-Peiffer C, Laybutt DR, Burchfield JG, Gurisik E, Narasimhan S, Mitchell CJ, Pedersen DJ, Braun U, Cooney GJ, Leitges M, Biden TJ. Inhibition of PKC epsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab 2007; 6:320-328
Laybutt DR, Preston AM, Åkerfeldt MC, Kench JG, Busch AK, Biankin AV, Biden TJ. Endoplasmic reticulum stress contributes to β-cell apoptosis in type 2 diabetes. Diabetologia 2007; 50: 752-763
Kjørholt C, Åkerfeldt MC, Biden TJ, Laybutt DR. Chronic Hyperglycemia, Independent of Plasma Lipid Levels, Is Sufficient for the Loss of {beta}-Cell Differentiation and Secretory Function in the db/db Mouse Model of Diabetes. Diabetes 2005; 54(9):2755-63.
Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, Bonner-Weir S, Weir GC. Critical reduction in β-cell mass results in two distinct outcomes over time. J Biol Chem 2003; 278:2997-3005.
Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas J-C, Groff A, Ferran F, Bonner-Weir S, Sharma A, Weir GC. Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes 2002; 51:413-423
Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC. Genetic regulation of metabolic pathways in β-cells disrupted by hyperglycemia. J Biol Chem 2002; 277:10912-21
Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S. Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression and diabetes. Diabetes 2002; 51:1793-1804
Jonas JC, Laybutt DR, Steil GM, Trivedi N, Pertusa JG, de Casteele MV, Weir GC, Henquin JC. High glucose stimulates early response gene c-Myc expression in rat pancreatic beta-cells. J Biol Chem 2001; 276:35375-35381
Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell 2001; 7:1165-1176
