Dr Shane T Grey
Senior Research Fellow; Group Leader, Gene Therapy & Autoimmunity Group, Immunology Program, Garvan Institute of Medical Research; Conjoint Senior Lecturer, Department of Medicine, The University of New South Wales
Email: s.grey 'at' garvan.org.au
Research Group: Grey
Education
2001-2003 Assistant Professor in Surgery, Harvard Medical School, Boston, USA
2000 Instructor in Surgery, Harvard Medical School, Boston, USA
1995-1999 Post Doctoral Fellow, Harvard Medical School, Boston, USA
1995 PhD Monash University, Melbourne
1988 BSc (Honours) Monash University, Melbourne
1985 BSc La Trobe University, Melbourne
Awards and Honours
2007 Key Opinion Leader (KOL) Award, The Transplantation Society International
2005 & 2008 Mary Kugel Award for services to the Juvenile Diabetes Foundation
2003 NSW BioFirst Award, Australia
2000 Career Development Award, Juvenile Diabetes Research Foundation International
Publications
Marino E, Villanueva J, Walters S, Liuwantara D, Mackay F, Grey ST. CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells. Diabetes 2009; 58(7):1568-77.
Webster KE, Walters S, Kohler RE, Mrkvan T, Boyman O, Surh CD, Grey ST, Sprent J. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med 2009; 206(4):751-60.
Walters S, Webster KE, Sutherland A, Gardam S, Groom J, Liuwantara D, Mariño E, Thaxton J, Weinberg A, Mackay F, Brink R, Sprent J, Grey ST. Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses. J Immunol. 2009 Jan 15;182(2):793-801
Mariño E, Batten M, Groom J, Walters S, Liuwantara D, Mackay F, Grey ST. Marginal-zone B-cells of nonobese diabetic mice expand with diabetes onset, invade the pancreatic lymph nodes, and present autoantigen to diabetogenic T-cells. Diabetes 2008; 57:395-404.
Mariño E, Grey ST. A new role for an old player: do B cells unleash the self-reactive CD8+ T cell storm necessary for the development of type 1 diabetes? J Autoimmun. 2008 Nov;31(3):301-5.
Liuwantara D, Elliot M, Smith MW, Yam AO, Walters SN, Marino E, McShea A, Grey ST. Nuclear factor-kappaB regulates beta-cell death: a critical role for A20 in beta-cell protection. Diabetes 2006; 55(9):2491-501.
Silveira PA, Grey ST. B cells in the spotlight: innocent bystanders or major players in the pathogenesis of type 1 diabetes. Trends Endocrinol Metab 2006; 17(4):128-35.
Daniel S, Arvelo MB, Patel VI, Longo CR, Shrikhande G, Shukri T, Mahiou J, Sun DW, Mottley C, Grey ST, Ferran C. A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. Blood 2004; 104(8):2376-84.
Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest 2003; 112(12):1831-42.
Grey ST, Longo C, Shukri T, Patel VI, Csizmadia E, Daniel S, Arvelo MB, Tchipashvili V, Ferran C. Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function. J Immunol 2003; 170(12):6250-6.
Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C. A20 inhibits cytokine-induced apoptosis and NF β dependent gene activation in islets. J Exp Med 1999; 190 (8): 1135-1145.
