Dr Stuart Tangye
Principal Research Fellow; Group Leader, Immunology and Inflammation Program, Garvan Institute of Medical Research; NHMRC Senior Research Fellow; Senior Lecturer (conjoint appointment), The University of New South Wales
Email: s.tangye 'at' garvan.org.au
Research Group: Immunology and Immunodeficiency
Education
1996 PhD, University of Technology Sydney
1991 BSc (Honours), University of Technology Sydney
1990 BSc, University of Technology Sydney
Awards and Honours
2008-2012: NHMRC Senior Research Fellow (level B)
2006 Young Tall Poppy Award
2004-2008 RD Wright Career Biomedical Development Award
1999-2002 U2000 Postdoctoral research fellowship and grant
Publications
KL Good, DT Avery and SG Tangye. 2009. Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naïve B cells. J Immunol. 182: 890-901DT Avery, CS Ma, VL Bryant, B Santner-Nanan, R Nanan, M Wong, DA Fulcher, MC Cook and SG Tangye. 2008. STAT3 is required for IL-21-mediated generation of IgE-secreting cells from human naïve B cells. Blood 112: 1784-1793
CS Ma, GYJ Chew, N Simpson, A Priyadarshi, M Wong, B Grimbacher, DA Fulcher, SG Tangye*, MC Cook* (equal contribution). 2008. Hyper IgE syndrome due to mutations in STAT3 represents a Th17 deficiency. J Exp Med 205: 1551-1557.
DT Avery, VL Bryant, CS Ma, R de Waal Malefyt, and SG Tangye. 2008. IL-21-induced isotype switching to IgG and IgA by human naïve B cells is differentially regulated by IL-4. J Immunol 181: 1767-1779
KL Good, VL Bryant and SG Tangye. 2006. Kinetics of human B cell behaviour and amplification of B cell responses following stimulation with IL-21. J Immunol 177: 5236-5247.
KL Good and SG Tangye. 2007. Decreased expression of Krüppel-like factors in memory B cells induces the accelerated response typical of secondary antibody responses. Proc Natl Acad Sci USA. 104: 13420-13425.
VL Bryant, CS Ma, DT Avery, Y Li, KL Good, LM Corcoran, R de Waal Malefyt and SG Tangye. 2007. Cytokine-mediated regulation of human B-cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol 179: 8180-8190.
Ma CS, Pittaluga S, Avery DT, Hare NJ, Maric I, Klion AD, Nichols KE, Tangye SG. Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease. J Clin Invest 2006; 116(2):322-33.
Ma CS, Hare NJ, Nichols KE, Dupre L, Andolfi G, Roncarolo MG, Adelstein S, Hodgkin PD, Tangye SG. Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells. J Clin Invest 2005; 115(4):1049-59.
Ellyard JI, Avery DT, Phan TG, Hare NJ, Hodgkin PD, Tangye SG. Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow. Blood 2004; 103(10):3805-12.
Avery DT, Kalled SL, Ellyard JI, Ambrose C, Bixler SA, Thien M, Brink R, Mackay F, Hodgkin PD, Tangye SG. BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. J Clin Invest 2003; 112(2):286-97.
Tangye SG, Avery DT, Deenick EK, Hodgkin PD. Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses. J Immunol 2003; 170(2):686-94.
Tangye SG, Avery DT, Hodgkin PD. A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells. J Immunol 2003; 170(1):261-9.
Tangye SG, Phillips JH, Lanier LL, Nichols KE. Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. J Immunol 2000; 165(6):2932-6.
Tangye SG, Liu YJ, Aversa G, Phillips JH, de Vries JE. Identification of functional human splenic memory B cells by expression of CD148 and CD27. J Exp Med 1998; 188(9):1691-703.
