Dr Will Hughes
Senior Research Officer; Group Leader, Diabetes and Obesity Research Program; Director, Pieter Huveneers Molecular Imaging Facility, Garvan Institute of Medical Research; Conjoint Senior Lecturer, Faculty of Medicine, The University of New South Wales
Email: w.hughes 'at' garvan.org.au
Research Group: Hughes
Education
1996 PhD University of Leicester, UK
1992 MSc University of Leicester, UK
1990 BSc (Hons) University of Bristol, UK
Awards
2002 Howard Florey Centenary Fellowship
2002 Royal Society Travelling Fellowship
1998 ICRF Postdoctoral Research Fellowship
1996 GlaxoWellcome Postdoctoral Research Fellowship
Publications
Burchfield, J. G., Lopez, J. A., Mele, K., Vallotton, P., James, D. E. and W. E. Hughes (2010) Exocytotic Vesicle Behaviour Assessed by Total Internal Reflection Fluorescence Microscopy.
Traffic, IN PRESS
Lopez, J. A., Burchfield, J. G., Blair, D. H., Mele, K., Ng, Y., Vallotton, P. A., James, D. E. and W. E. Hughes (2009) Identification of a Distal GLUT4 Trafficking Event Controlled by Actin Polymerisation. Molecular Biology of the Cell, 20, 3918-3929
Mele, K., Vallotton, P., Burchfield, J. G., James, D. E. and W. E. Hughes (2009)
Towards fully automated Identification of Vesicle-Membrane Fusion Events in TIRF Microscopy.
International Journal of Computer Aided Engineering and Technology, 1, 502-515
Cazzolli, R., Huang, P. Teng, S and W. E. Hughes (2009) Measuring Phospholipase D activity in Insulin secreting and Insulin Responsive Cells and Tissues.
Methods in Molecular Biology 462, 241-251.
Katsoulotos, G. P., Qi, M., Qi, J. C., Tanaka, K., Hughes, W. E. Molloy, T. J., Adachi, R., Stevens, R. L. and S. A. Krilis, (2008) The Diacylglycerol Dependent Translocation of Ras Guanine Nucleotide-Releasing Protein 4 (RasGRP4) Inside a Human Mast Cell Line Results in Substantial Phenotypic Changes Including Expression of the Interleukin 13 Receptor IL13Rα2.
Journal of Biological Chemistry 283, 1610-1621.
Sluyter, R., Shemon, A.N., Hughes, W. E., Stevenson, R.O., Georgiou, J.G., Eslick, G.D., Taylor, R.M. and J. S. Wiley. (2007) Canine erythrocytes express the P2X7 receptor: greatly increased function compared to human erythrocytes.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 293, 2090-2098.
Falasca, M., Hughes, W. E., Dominguez, V., Sala, G., Fostira, F., Fang, M.Q., Cazzolli, R., Shepherd, P.R., James, D. E., and T. Maffucci, (2007) The Role of Phosphoinositide 3-Kinase C2a in Insulin Signalling.
Journal of Biological Chemistry 282, 28226-28236.
Cazzolli, R., Shemon, A.N., Fang, M. Q. and W. E. Hughes (2006) Phospholipid Signalling via Phospholipase D and Phosphatidic Acid.
IUBMB Life 58, 458-461
Rentero, C., Evans, R., Wood, P., Tebar, F., Vila de Muga, S., Cubells, L., de Diego, I., Hayes, T.E., Hughes, W. E., Pol, A., Rye, K.A., Enrich, C. and T. Grewal (2006). Inhibition of H-Ras and MAPK is compensated by PKC-dependent pathways in Annexin A6 expressing cells.
Cellular Signalling 18, 1006-1016.
Ludowyke, R.I., Elgundi, Z. Kranenburg, T., Stehn, J.R., Schmitz-Peiffer, C., Hughes, W. E. and T. J. Biden (2006). Phosphorylation of non-muscle myosin heavy chain IIA on serine-1917 is mediated by protein kinase CbetaII and coincides with the onset of stimulated degranulation in RBL-2H3 mast cells. Journal of Immunology 177, 1492-1499
