Professor Roger Daly
Principal Research Fellow; Group Leader, Cancer Research Program, Garvan Institute of Medical Research; NHMRC Principal Research Fellow; Conjoint Professor, Faculty of Medicine, The University of New South Wales
Email: r.daly 'at' garvan.org.au
Research Group: Signal Transduction
This led to an interest in growth factor action, and combined with exciting developments in the signalling field in the late 1980's, drew Roger into the analysis of tyrosine kinase signalling mechanisms. His second postdoc, with Joseph Schlessinger at New York University, led to the cloning and characterisation of Grb2, which established a paradigm for adapter protein signalling. This research resulted in a joint first author Cell paper that has been cited more than 1000 times. Roger’s next move was to the Garvan Institute in 1993. His Signal Transduction Group cloned Grb14 and determined that it is a physiological regulator of insulin action. They have also found a new role for the cytoskeletal protein cortactin in preventing degradation of a cell surface receptor involved in cancer development.
Education
1988 PhD University of Liverpool
1984 BSc (Hons) Class I University of Liverpool
Publications
Brummer T, Schramek D, Hayes VM et al. Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J Biol Chem 2006; 281:626-637.
Timpson P, Lynch DK, Schramek D et al. Cortactin overexpression inhibits ligand-induced downregulation of the epidermal growth factor receptor. Cancer Res 2005; 65:3273-3280.
Cooney GJ, Lyons RJ, Crew AJ, Jensen TE, Molero JC, Mitchell CJ, Biden TJ, Ormandy CJ, James DE and Daly RJ. Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice. Embo J 2004; 23:582-593.
Lynch DK, Winata SC, Lyons RJ, Hughes WE, Lehrbach GM, Wasinger V, Corthals G, Cordwell S, Daly RJ. A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. J Biol Chem 2003; 278: 21805-21813.
Daly RJ, Gu H, Parmar J, Malaney S, Lyons RJ, Kairouz R, Head DR, Henshall SM, Neel BG, Sutherland RL. The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer. Oncogene 2002; 21:5175-5181.
Lynch DK, Daly RJ. PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. Embo J 2002; 21:72-82.
Lyons RJ, Deane R, Lynch DK, Ye ZS, Sanderson GM, Eyre HJ, Sutherland GR, Daly RJ. Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14. J Biol Chem 2001; 276:17172-17180.
Campbell DH, Sutherland RL, Daly RJ. Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin. Cancer Res 1999; 59:5376-5385.
Daly RJ, Sanderson GM, Janes PW, Sutherland RL. Cloning and characterization of GRB14, a novel member of the GRB7 gene family. J Biol Chem 1996; 271:12502-12510.
Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 1992; 70: 431-442.
