B Cell Immunobiology
Autoimmune diseases such as lupus, myasthenia gravis and hemolytic
anemia can arise when B cells produce rogue antibodies that attack the
body. Our investigations aim to identify the specific genes and
signalling pathways that regulate B cell survival, proliferation, and
differentiation; as well as the molecules and cells that drive antibody
production against foreign structures and prevent antibody responses
against ourselves. By understanding how B cells function we hope to
reveal new strategies for improving vaccines, controlling autoimmune
disease, and treating B cell malignancies.
Staff
 Research OfficerDr Dominique Gatto |
 Postgraduate StudentTyani Chan |
Catherine Wood |
|
News
Mystery solved at crossroads of immune response
MEDIA RELEASE:
17 Jul 2009
Garvan scientists have solved an important mystery about our immune response, a finding that among other things could be used to help improve the body's reaction to vaccination.
How germs meet their opposites - a mystery revealed in real time
MEDIA RELEASE:
09 Jun 2009
Sophisticated microscope technology has made it possible for Australian and American scientists to record previously unknown interactions between two classes of immune cell right at the beginning of the 'antigen transport chain', the apex of the immune response. An important discovery, this takes us one step further towards being able to control disease and infection.
B cell mutations that may cause cancers and autoimmune diseases
MEDIA RELEASE:
29 Feb 2008
To remain healthy, we must maintain exactly the right number of B cells, the white blood cells that produce antibodies. Scientists at Garvan have identified the factors critical to maintaining this important balance within our immune systems. When the balance fails, we become prone to developing certain cancers or autoimmune diseases.
