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Garvan Institute

Sections
 

Bone Genetics and Epidemiology

 

Group Leader
Professor John Eisman AO

 
Group Leader
Dr Jackie Center

 
Group Leader
Associate Professor Tuan Nguyen

 

Our research draws on the Dubbo Osteoporosis Epidemiology Study (DOES), which began in 1989 and is the world’s longest running large-scale epidemiological study of osteoporotic fractures in men and women.

We are using the DOES data to develop predictive models, based on multiple risk factors, to identify men and women at high risk of bone fractures and to determine who would benefit most from preventative interventions.

We are also continuing to search for new osteoporosis genes that may predict those who are at low risk of osteoporosis and bone fractures – taking into account environmental factors such as physical activity, dietary habits, medication, fall-related and hormonal factors.

Finding and understanding how these genes work and interact with other known genes will help identify targets for novel therapies.

Staff

Clinical Research Associate
Janet Watters
Clinical Research Associate
Shaye Field
Clinical Research Associate
Glenys Hubbard
nguyen_nguyen90.JPGResearch Officer
Dr Nguyen Nguyen
Dana BliucPhD Student
Dana Bliuc
Bich TranPhD Student
Bich Tran
Heather GordonResearch Assistant
Heather Gordon

News

 

Study shows that prostate cancer increases the risk of bone fracture

MEDIA RELEASE: 14 May 2008
As unlikely as it sounds, scientists at Garvan have shown that there is a link between prostate cancer and a higher risk of bone fracture. Their study suggests that men with prostate cancer face a 50% higher risk of fracture, which increases to nearly 100% if they are receiving androgen deprivation therapy for their prostate cancer.
 
 

Genotyping takes us closer to an osteoporosis fingerprint

MEDIA RELEASE: 30 Apr 2008
Garvan collaborated with the Icelandic genetics company, deCode, in an extensive multi-nation genome-wide search to find the genes linked to osteoporosis and fracture. Five regions of interest have been identified that appear to warrant further scientific investigation.
 
 

Web-based tool to predict risk of bone fracture

MEDIA RELEASE: 06 Mar 2008
Scientists from Garvan have developed a fracture risk calculator using data, accumulated over 17 years, from the internationally recognised Dubbo Osteoporosis Epidemiology Study. A paper describing the tool and its methodology was published today in the prestigious international journal, Osteoporosis International.
 
 

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