Epigenetics
Cancer cells deactivate large regions of DNA by a biochemical
process called methylation. Our research focuses on understanding the
process that triggers abnormal methylation and demethylation between
normal and cancer cells. We have developed different methods to detect
methylation changes during development and have noticed that these
‘epigenetic’ changes can take place across very large regions of DNA
during cancer development. We are trying to work out the sequence of
events so that we can try to reverse the process, as we believe these
regions may contain genes that normally prevent the development of
tumours.
Staff
Associate Professor Marie Dziadek |
Dr Marcel Coolen |
Dr James Devaney |
Dr Clare Stirzaker |
Dr Toby Hulf |
Dr Jenny Song |
Wenjia Qu |
Research Assistant Zena Kassir |
| Research Assistant Saul Bert |
Wendy Ng |
Rebecca Hinshelwood |
PhD Student Aaron Statham |
Recent publication
As published in Nucleic Acids Research (see below), our lab has
developed software to assist in the design and analysis of experiments
measuring DNA methylation using the Sequenom MassARRAY platform. Click
here to download.
For question and comments, please contact Aaron Statham ( a.statham'at'garvan.org.au).
Ref: Coolen MW, Statham A, Gardiner-Garden M, Clark SJ. Genomic
profiling of CpG methylation and allelic specificity using quantitative
high-throughput mass spectrometry: critical evaluation and
improvements. Nucleic Acids Research 2007:10.1093/nar/gkm662.
