Integrin and Cell Biology
The signaling pathways that control normal development are often
disrupted during cancer. Our research aims to understanding the
mechanisms behind the regulation of cell fate decisions during these
processes and the progression to metastatic disease. Cell-matrix
adhesion mediated by integrins, provides cells with both a positional
identity and coordinates growth factor and hormone signaling to control
cell function. The initiation and progression of cancer is dependent on
the ability of a cell to acquire the means to circumvent this
regulation and as such modulation of integrin function can alter tumour
phenotype. We are currently investigating integrin function during
mammary and prostate gland development and in experimental models of
carcinogenesis and metastasis. In addition we are also investigating
the role of several cell fate transcriptional regulators also during
mammary gland development, cancer and metastasis.
Staff
Dr Renee Rogers |
Anita Ledger |
