Lung and Colorectal Cancer
We examine the gene profiles of cancer specimens obtained from patients whose clinical outcomes are already known. The challenge is to work out which key gene alterations are the most useful for determining prognosis and treatment outcomes. We have identified new genes that are inactivated through methylation, a poorly understood molecular mechanism promoting cancer development. Methylation can be identified from surgically resected cancers or tumour biopsies in the research laboratory but this is not routinely carried out in clinical practice. Our aim is to develop genetic tests that can be applied at the hospital laboratories. We also want to understand the biological significance of the gene defects, which will enable development of new treatment strategies.
Staff
 Research OfficerDr Laurent Pangon |
 Research OfficerDr Nicholas Sigglekow |
 Research AssistantNicola Currey |
 Research
AssistantJessica Fitch |
 Research AssistantMelissa Abas |
 PhD StudentSam Al-Sohaily |
 PhD StudentDessislava Mladenova |
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| Visiting/Honorary Researchers Dr Tina Selinger Wendy Cooper Joseph Daniel Patricia Kho Jason Tseung Dr Po Yee Yip |
