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Professor Thomas Cox

Role
Laboratory Head
Lab/Group
Matrix and Metastasis Lab

A/Prof. Thomas Cox is a cancer cell biologist working in the field of the extracellular matrix and matrix remodelling in the progression and metastasis of solid tumours. He graduated with a Ph.D. from the University of Durham, UK in 2008, followed by PostDoctoral research positions at the Institute of Cancer Research (ICR) in London, UK and Copenhagen University, Denmark. In 2016 he was recruited to the Garvan Institute in Sydney, Australia to establish his own independent research group.

Thomas currently leads the Matrix and Metastasis Lab, part of the Cancer Ecosystems Program at the Garvan Institute and Kinghorn Cancer Centre in Sydney. The labs creative research program integrates matrix biology with precision oncology, to make fundamental advances in personalised stromal targeting of solid tumours.

The team’s work is focused on tackling the knowledge gap in and redefining our understanding of the matrix in diseases such as cancer. The lab strives to identify new matrix targets and matrix targeting approaches, as well as develop ways to maximise their effectiveness in pre-clinical small animal cancer models (breast, pancreatic, lung) for personalising novel and/or current anti-cancer agents.

Thomas also takes an active role in training emerging scientists. He is the immediate Past-President of the Matrix Biology Society of Australia and New Zealand (MBSANZ) as well as the Director of Communications for the international Metastasis Research Society (MRS), in addition to being an Executive Board Member. Thomas is also a cofounder, and executive member of the Australian Pancreatic Cancer Matrix Atlas (APMA).

Awards

  • 2023Matrix Biology Society of Australia & New Zealand (MBSANZ) Barry Preston Award
  • 2020Matrix Biology Society of Australia & New Zealand (MBSANZ) Paper of the Year 2020
  • 2019NHMRC RD Wright Biomedical Career Development Fellowship Level 2
  • 2018Cancer Institute New South Wales (CINSW) Career Development Fellowship
  • 2017Ridley Ken Davies Award for future scientific leaders delivering breakthrough medical research
  • 2016British Society for Matrix Biology (BSMB) John Scott Young Investigator Award for significant contributions to matrix biology
  • 2016Journal of Biological Chemistry (JBC) Herbert Tabor Young Investigator Award for creativity - innovation and scientific excellence

Selected publications

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  • 2024
    Advanced Science (Weinheim, Baden-Wurttemberg, Germany)10.1002/advs.202307963

    Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism.

    Elysse C Filipe, Sipiththa Velayuthar, Ashleigh Philp, Max Nobis, Sharissa L Latham, Amelia L Parker, Kendelle J Murphy, Kaitlin Wyllie, Gretel S Major, Osvaldo Contreras, Ellie T Y Mok, Ronaldo F Enriquez, Suzanne McGowan, Kristen Feher, Lake-Ee Quek, Sarah E Hancock, Michelle Yam, Emmi Tran, Yordanos F I Setargew, Joanna N Skhinas, Jessica L Chitty, Monica Phimmachanh, Jeremy Z R Han, Antonia L Cadell, Michael Papanicolaou, Hadi Mahmodi, Beata Kiedik, Simon Junankar, Samuel E Ross, Natasha Lam, Rhiannon Coulson, Jessica Yang, Anaiis Zaratzian, Andrew M Da Silva, Michael Tayao, Ian L Chin, Aurélie Cazet, Maya Kansara, Davendra Segara, Andrew Parker, Andrew J Hoy, Richard P Harvey, Ozren Bogdanovic, Paul Timpson, David R Croucher, Elgene Lim, Alexander Swarbrick, Jeff Holst, Nigel Turner, Yu Suk Choi, Irina V Kabakova, Andrew Philp, Thomas R Cox
  • 2023
    Nature Cancer10.1038/s43018-023-00614-y

    A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer.

    Jessica L Chitty, Michelle Yam, Lara Perryman, Amelia L Parker, Joanna N Skhinas, Yordanos F I Setargew, Ellie T Y Mok, Emmi Tran, Rhiannon D Grant, Sharissa L Latham, Brooke A Pereira, Shona C Ritchie, Kendelle J Murphy, Michael Trpceski, Alison D Findlay, Pauline Melenec, Elysse C Filipe, Audrey Nadalini, Sipiththa Velayuthar, Gretel Major, Kaitlin Wyllie, Michael Papanicolaou, Shivanjali Ratnaseelan, Phoebe A Phillips, George Sharbeen, Janet Youkhana, Alice Russo, Antonia Blackwell, Jordan F Hastings, Morghan C Lucas, Cecilia R Chambers, Daniel A Reed, Janett Stoehr, Claire Vennin, Ruth Pidsley, Anaiis Zaratzian, Andrew M Da Silva, Michael Tayao, Brett Charlton, David Herrmann, Max Nobis, Susan J Clark, Andrew V Biankin, Amber L Johns, David R Croucher, Adnan Nagrial, Anthony J Gill, Sean M Grimmond, , , Marina Pajic, Paul Timpson, Wolfgang Jarolimek, Thomas R Cox
  • 2022
    Genome Medicine10.1186/s13073-022-01127-6

    Extracellular matrix profiles determine risk and prognosis of the squamous cell carcinoma subtype of non-small cell lung carcinoma.

    Amelia L Parker, Elise Bowman, Adriana Zingone, Brid M Ryan, Wendy A Cooper, Maija Kohonen-Corish, Curtis C Harris, Thomas R Cox
  • 2022
    Nature Communications10.1038/s41467-022-32255-7

    Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis.

    Michael Papanicolaou, Amelia L Parker, Michelle Yam, Elysse C Filipe, Sunny Z Wu, Jessica L Chitty, Kaitlin Wyllie, Emmi Tran, Ellie Mok, Audrey Nadalini, Joanna N Skhinas, Morghan C Lucas, David Herrmann, Max Nobis, Brooke A Pereira, Andrew M K Law, Lesley Castillo, Kendelle J Murphy, Anaiis Zaratzian, Jordan F Hastings, David R Croucher, Elgene Lim, Brian G Oliver, Fatima Valdes Mora, Benjamin L Parker, David Gallego-Ortega, Alexander Swarbrick, Sandra O'Toole, Paul Timpson, Thomas R Cox
  • 2021
    Nature Reviews. Cancer10.1038/s41568-020-00329-7

    The matrix in cancer.

    Thomas R Cox