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Daniel Suan

Dr Daniel Suan

Role
Clinical Director Hope Research Project
Lab/Group
Immunogenomics Lab

Dr Dan Suan grew up in Perth and studied medicine at UWA before moving to Sydney to train as an Immunologist at Westmead Hospital and St Vincent's Hospital. After this, he completed his PhD in 2015 in the lab of Professor Rob Brink at Garvan, using transgenic mouse models to investigate memory B cell and plasma cell differentiation in the germinal centre response, the mechanism by which the human immune system forms antibodies and long-lived memory against infection and vaccination.

Dan was appointed as a Staff Specialist in Clinical Immunology and Immunopathology at Westmead Hospital in 2015, where he cares for patients with a wide range of immune conditions, including autoimmune diseases, allergies, immunodeficiencies and HIV infection. Dan has a longstanding interest and commitment to teaching and training, and is a Conjoint Senior Lecturer at both the University of Sydney and UNSW. He remained part-time at Garvan to continue his research training and establish a genomics program to study the cause of human autoimmune disorders under the supervision of Professor Chris Goodnow.

The ambitious Hope Research program is studying over 40 autoimmune diseases, including CREST syndrome, psoriatic arthritis, lupus, Sjogren's syndrome, multiple sclerosis and inclusion body myositis, utilising the latest single-cell sequencing technologies. Dan’s research has been supported by funding from the NHMRC, UNSW Triple I, Multiple Sclerosis Research Australia and by generous philanthropic donations and support from community bodies.

Selected publications

See all publications
  • 2023
    Nature10.1038/s41586-023-06717-x

    Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency.

    Tom Le Voyer, Audrey V Parent, Xian Liu, Axel Cederholm, Adrian Gervais, Jérémie Rosain, Tina Nguyen, Malena Perez Lorenzo, Elze Rackaityte, Darawan Rinchai, Peng Zhang, Lucy Bizien, Gonca Hancioglu, Pascale Ghillani-Dalbin, Jean-Luc Charuel, Quentin Philippot, Mame Sokhna Gueye, Majistor Raj Luxman Maglorius Renkilaraj, Masato Ogishi, Camille Soudée, Mélanie Migaud, Flore Rozenberg, Mana Momenilandi, Quentin Riller, Luisa Imberti, Ottavia M Delmonte, Gabriele Müller, Baerbel Keller, Julio Orrego, William Alexander Franco Gallego, Tamar Rubin, Melike Emiroglu, Nima Parvaneh, Daniel Eriksson, Maribel Aranda-Guillen, David I Berrios, Linda Vong, Constance H Katelaris, Peter Mustillo, Johannes Raedler, Jonathan Bohlen, Jale Bengi Celik, Camila Astudillo, Sarah Winter, , , Catriona McLean, Aurélien Guffroy, Joseph L DeRisi, David Yu, Corey Miller, Yi Feng, Audrey Guichard, Vivien Béziat, Jacinta Bustamante, Qiang Pan-Hammarström, Yu Zhang, Lindsey B Rosen, Steve M Holland, Marita Bosticardo, Heather Kenney, Riccardo Castagnoli, Charlotte A Slade, Kaan Boztuğ, Nizar Mahlaoui, Sylvain Latour, Roshini S Abraham, Vassilios Lougaris, Fabian Hauck, Anna Sediva, Faranaz Atschekzei, Georgios Sogkas, M Cecilia Poli, Mary A Slatter, Boaz Palterer, Michael D Keller, Alberto Pinzon-Charry, Anna Sullivan, Luke Droney, Daniel Suan, Melanie Wong, Alisa Kane, Hannah Hu, Cindy Ma, Hana Grombiříková, Peter Ciznar, Ilan Dalal, Nathalie Aladjidi, Miguel Hie, Estibaliz Lazaro, Jose Franco, Sevgi Keles, Marion Malphettes, Marlene Pasquet, Maria Elena Maccari, Andrea Meinhardt, Aydan Ikinciogullari, Mohammad Shahrooei, Fatih Celmeli, Patrick Frosk, Christopher C Goodnow, Paul E Gray, Alexandre Belot, Hye Sun Kuehn, Sergio D Rosenzweig, Makoto Miyara, Francesco Licciardi, Amélie Servettaz, Vincent Barlogis, Guillaume Le Guenno, Vera-Maria Herrmann, Taco Kuijpers, Grégoire Ducoux, Françoise Sarrot-Reynauld, Catharina Schuetz, Charlotte Cunningham-Rundles, Frédéric Rieux-Laucat, Stuart G Tangye, Cristina Sobacchi, Rainer Doffinger, Klaus Warnatz, Bodo Grimbacher, Claire Fieschi, Laureline Berteloot, Vanessa L Bryant, Sophie Trouillet Assant, Helen Su, Benedicte Neven, Laurent Abel, Qian Zhang, Bertrand Boisson, Aurélie Cobat, Emmanuelle Jouanguy, Olle Kampe, Paul Bastard, Chaim M Roifman, Nils Landegren, Luigi D Notarangelo, Mark S Anderson, Jean-Laurent Casanova, Anne Puel
  • 2022
    Immunity10.1016/j.immuni.2022.11.001

    STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2D CD8 T cell dysregulation and accumulation.

    Etienne Masle-Farquhar, Katherine J L Jackson, Timothy J Peters, Ghamdan Al-Eryani, Mandeep Singh, Kathryn J Payne, Geetha Rao, Danielle T Avery, Gabrielle Apps, Jennifer Kingham, Christopher J Jara, Ksenia Skvortsova, Alexander Swarbrick, Cindy S Ma, Daniel Suan, Gulbu Uzel, Ignatius Chua, Jennifer W Leiding, Kaarina Heiskanen, Kahn Preece, Leena Kainulainen, Michael O'Sullivan, Megan A Cooper, Mikko R J Seppänen, Satu Mustjoki, Shannon Brothers, Tiphanie P Vogel, Robert Brink, Stuart G Tangye, Joanne H Reed, Christopher C Goodnow
  • 2022
    The Journal of Allergy and Clinical Immunology10.1016/j.jaci.2022.09.002

    Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome.

    Jennifer W Leiding, Tiphanie P Vogel, Valentine G J Santarlas, Rahul Mhaskar, Madison R Smith, Alexandre Carisey, Alexander Vargas-Hernández, Manuel Silva-Carmona, Maximilian Heeg, Anne Rensing-Ehl, Bénédicte Neven, Jérôme Hadjadj, Sophie Hambleton, Timothy Ronan Leahy, Kornvalee Meesilpavikai, Charlotte Cunningham-Rundles, Cullen M Dutmer, Svetlana O Sharapova, Mervi Taskinen, Ignatius Chua, Rosie Hague, Christian Klemann, Larysa Kostyuchenko, Tomohiro Morio, Akaluck Thatayatikom, Ahmet Ozen, Anna Scherbina, Cindy S Bauer, Sarah E Flanagan, Eleonora Gambineri, Lisa Giovannini-Chami, Jennifer Heimall, Kathleen E Sullivan, Eric Allenspach, Neil Romberg, Sean G Deane, Benjamin T Prince, Melissa J Rose, John Bohnsack, Talal Mousallem, Rohith Jesudas, Maria Marluce Dos Santos Vilela, Michael O'Sullivan, Jana Pachlopnik Schmid, Štěpánka Průhová, Adam Klocperk, Matthew Rees, Helen Su, Sami Bahna, Safa Baris, Lisa M Bartnikas, Amy Chang Berger, Tracy A Briggs, Shannon Brothers, Vanessa Bundy, Alice Y Chan, Shanmuganathan Chandrakasan, Mette Christiansen, Theresa Cole, Matthew C Cook, Mukesh M Desai, Ute Fischer, David A Fulcher, Silvanna Gallo, Amelie Gauthier, Andrew R Gennery, José Gonçalo Marques, Frédéric Gottrand, Bodo Grimbacher, Eyal Grunebaum, Emma Haapaniemi, Sari Hämäläinen, Kaarina Heiskanen, Tarja Heiskanen-Kosma, Hal M Hoffman, Luis Ignacio Gonzalez-Granado, Anthony L Guerrerio, Leena Kainulainen, Ashish Kumar, Monica G Lawrence, Carina Levin, Timi Martelius, Olaf Neth, Peter Olbrich, Alejandro Palma, Niraj C Patel, Tamara Pozos, Kahn Preece, Saúl Oswaldo Lugo Reyes, Mark A Russell, Yael Schejter, Christine Seroogy, Jan Sinclair, Effie Skevofilax, Daniel Suan, Daniel Suez, Paul Szabolcs, Helena Velasco, Klaus Warnatz, Kelly Walkovich, Austen Worth, , Mikko R J Seppänen, Troy R Torgerson, Georgios Sogkas, Stephan Ehl, Stuart G Tangye, Megan A Cooper, Joshua D Milner, Lisa R Forbes Satter