Dr Neil Portman
Dr Neil Portman completed his PhD in the field of molecular cell biology at the University of Oxford, UK. He worked on the single-celled eukaryotic parasite Trypanosoma brucei, etiological agent of African sleeping sickness, with a particular focus on the cytoskeleton and flagellum. He moved to the University of Sydney in 2012 after being awarded a Vice Chancellor’s postdoctoral fellowship to continue his interest in the biology of the eukaryotic flagellum in another model of parasitic disease, the apicomplexan.
After a short career break being a full-time dad, he joined the Connie Johnson Breast Cancer Research Group at the Garvan Institute of Medical Research where he is applying his background in molecular biology, genome editing and proteomics techniques to generate and interrogate models of endocrine resistant breast cancer with the aim of identifying novel therapeutic strategies to improve outcomes for patients with advanced breast cancer.
Awards
- 2012University of Sydney Vice Chancellor’s Postdoctoral Research Fellowship
Selected publications
See all publications- 2024Cancer Research10.1158/0008-5472.CAN-24-0013
Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor-Targeted Therapy Drives Resistance in Breast Cancer.
- 2024The Journal of Clinical Investigation10.1172/JCI183583
Survival of men with metastatic hormone-sensitive prostate cancer and adrenal-permissive HSD3B1 inheritance.
- 2024Nature Structural & Molecular Biology10.1038/s41594-023-01181-7
The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer.
- 2023Cancer Communications (London, England)10.1002/cac2.12425
Triple combination targeting PI3K, ER, and CDK4/6 inhibits growth of ER-positive breast cancer resistant to fulvestrant and CDK4/6 or PI3K inhibitor.
- 2022Nature Cancer10.1038/s43018-021-00328-z
A new sophistication for breast cancer PDXs.