Lymphocyte Signalling and Activation Lab

We are interested in understanding these signals and how they can go wrong and lead to diseases such as immunodeficiency, allergy and autoimmunity (e.g. systemic lupus erythematosus, autoimmune cytopenias). To do this, we study both patient immune cells and mouse models, to track the signalling pathways that controlimmune activation and differentiation, and work out how this goes wrong in disease. Our aim is to better treat immune diseases, such as allergy and autoimmunity, by understanding the dysregulated immune signalling that drives it. This will then allow us to find therapies that directly target the drivers of each patient's disease.