Systems Immunology Group

Historically, the investigation of common complex diseases has typically employed a reductionist method, often overlooking the presence of multiple diseases. However, it is important to consider the interaction between different diseases, as it can significantly impact diagnosis and treatment and provide a clearer clinical picture of the patient.

The Systems Immunology Group's main objective is to gain insight into the genetic makeup of autoimmune diseases and how gene-environment interactions can lead to variations in molecular traits, resulting in the diverse clinical presentations of these diseases. By employing a systems biology approach, we examine individual electronic health records to uncover hidden disease phenotypes and compare the genetic, epigenetic, and transcriptional similarities and differences across these data-driven disease endophenotypes.